Yuzhang Wu
Director Institute of Immunology, China
Title: Achievements and challenges in post-exposure vaccine development
Biography
Biography: Yuzhang Wu
Abstract
As chronic diseases, such as tumor, persistent infections, autoimmune diseases, cognitive diseases and metabolic disorders, are the main health problems at present for human, there is a clear need for postexposure vaccines, most of which are therapeutic. To date few postexposure vaccines have been licensed to industry, although large amount of studies had been conducted in the past 20 years. There is a clear indication of the era of transformational development of vaccine. For postexposure vaccine development, we need clear target, novel strategy, and new technologies in vaccine design, adjuvant, and delivery systems. From the view of immunology, there are several challenges: Heterologous immunity, narrowed TCR repertoire, individual TCR usage, cross and pathologic reactivity, antigen load and heterologous immunity, immune deviation. This talk will summarize recent achievements in post-exposure vaccinology development and insight into challenges in immunology.