Shicheng Bi
Zhejing University, China
Title: Improved immune responses to live infectious bursa disease vaccine in chickens by oral administration of Rg1
Biography
Biography: Shicheng Bi
Abstract
The previous study demonstrated that ginseng stem-leaf saponins (GSLS) enhanced both humoral and gut mucosal immunity in chickens vaccinated with live infectious bursa disease vaccine. The present study was to evaluate Rg1, one of the major components in GSLS, for its effect on the immune response to live infectious bursa disease vaccine (IBDV) in chickens immunosuppressed by cyclophosphamide (Cy). Compared to the group immunized alone with IBDV, injection of Cy significantly suppressed the immunity in chickens. However, oral administration of Rg1 before immunization enhanced the immunity by exhibiting increased splenocyte proliferative response to ConA, improved spleen and bursa indices and enhanced specific antibody response to IBDV vaccine. Therefore, Rg1 may be one of the major components of ginseng stem-leaf saponins to improve vaccination in immunosuppressed chickens.