Andreas Suhrbier
QIMR Berghofer Medical Research Institute, Australia
Title: Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoproteinspecific equine IgG
Biography
Biography: Andreas Suhrbier
Abstract
We describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting
with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine
IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads
by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG
responses 9-15 days after infection, with circulating virus undetectable by day 15-17. Such equine IgG may find utility as a
post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with
extensive human safety data and WHO-standardized international manufacturing capability available in both high and low
income countries.