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Jean Marie Andrieu

Jean Marie Andrieu

Paris-Descartes University, France

Title: HIV replication is suppressed by CD8+T- regulatory cells in elite controllers

Biography

Biography: Jean Marie Andrieu

Abstract

We previously demonstrated in the Chinese macaque model that an oral vaccine made of inactivated SIV and Lactobacillus plantarum induced CD8+T-regulatory cells which suppressed the activation of SIV+CD4+T-cells, prevented SIV replication and protected macaques from SIV challenges (Lu et al., Cell Reports, 2012). Here ,we sought whether a similar population of CD8+T-regs would induce HIV replication suppression in Human elite controllers (ECs), a small population (3‰) of patients without HIV replication. For that purpose, we investigated the in vitro antiviral activity of fresh CD8+T-cells on HIV-infected CD4+T-cells taken from 10 ECs. The 10 ECs had a classical genomic profile: all of them carried the KIR3DL1 gene and 9/10 carried at least one allele of HLA-B:Bw4-80Ile ( i.e. with an isoleucine residue at position 80) . In the 9 HLA-B:Bw4-80Ile positive patients, we demonstrated a strong viral suppression by fresh KIR3DL1-expressing CD8+T-cells that required cell-to-cell contact to switch off the activation signals in infected CD4+T-cells. The neutralization of KIR3DL1 by an adequate anti-KIR antibody completely inhibited viral replication suppression.Our findings provide the first evidence for an instrumental role of KIR-expressing CD8+T-regulatory cells in the natural control of HIV-1 infection.

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